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	guillain-barre syndrome

Disease ID	192
Disease	guillain-barre syndrome
Definition	An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)
Synonym	gbs gbs - guillain-barre syndrome guillain barre disease guillain barre syndrome guillain barrÃ© syndrome guillain-barre disease guillain-barre syndrome (disorder) guillain-barre syndrome (gbs) guillain-barre syndrome [disease/finding] guillain-barre syndrome, familial guillain-barrÃ© syndrome guillain-barrÃ© syndrome (disorder) guillaine barre syndrome guillaine-barre syndrome gullian barre syndrome landry guillain barre syndrome landry paralysis landry's paralysis landry-guillain-barre syndrome landry-guillain-barrÃ© syndrome syndrome guillain-barre syndrome, guillain-barre syndrome, guillaine-barre syndrome, landry-guillain-barre
Orphanet	ORPHANET:2103
OMIM	OMIM:139393
DOID	DOID:12842
ICD10	ICD10CM:G61.0
UMLS	C0018378
MeSH	D020275
SNOMED-CT	SNOMEDCT_US_2016_09_01:40956001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:84) C0019158 \| hepatitis \| 7 C0085293 \| hepatitis e \| 7 C0442874 \| neuropathy \| 5 C0042769 \| virus infection \| 5 C0021400 \| influenza \| 4 C0393799 \| fisher syndrome \| 3 C1145670 \| respiratory failure \| 3 C0015464 \| facial nerve palsy \| 2 C0026769 \| multiple sclerosis \| 2 C0003864 \| arthritis \| 2 C0270921 \| axonal neuropathy \| 2 C0026934 \| mycoplasma \| 2 C0006818 \| campylobacter infection \| 2 C0032285 \| pneumoniae \| 2 C0878544 \| cardiomyopathy \| 2 C0032302 \| mycoplasma pneumonia \| 2 C0034152 \| henoch-schonlein purpura \| 1 C0011882 \| diabetic neuropathy \| 1 C0039144 \| syringomyelia \| 1 C0022658 \| nephropathy \| 1 C0003873 \| rheumatoid arthritis \| 1 C0023903 \| hepatic cancer \| 1 C0677607 \| hashimoto thyroiditis \| 1 C0004623 \| bacterial infection \| 1 C1847523 \| abducens palsy \| 1 C0276357 \| swine influenza \| 1 C0037928 \| myelopathy \| 1 C0041471 \| typhus \| 1 C0034735 \| raynaud's phenomenon \| 1 C0393799 \| miller fisher syndrome \| 1 C0035258 \| restless legs \| 1 C0041466 \| typhoid \| 1 C0036472 \| scrub typhus \| 1 C0409974 \| lupus erythematosus \| 1 C0162293 \| papillitis \| 1 C0035258 \| restless legs syndrome \| 1 C0011880 \| diabetic ketoacidosis \| 1 C0085273 \| parvovirus b19 infection \| 1 C0005697 \| neurogenic bladder \| 1 C0259749 \| autonomic neuropathy \| 1 C0007570 \| celiac disease \| 1 C0030443 \| periodic paralysis \| 1 C0027726 \| nephrotic syndrome \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0020255 \| hydrocephalus \| 1 C0034150 \| purpura \| 1 C0031511 \| pheochromocytoma \| 1 C0393819 \| chronic inflammatory demyelinating polyradiculoneuropathy \| 1 C0014057 \| japanese encephalitis \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0017605 \| angle-closure glaucoma \| 1 C0037317 \| sleep disturbance \| 1 C0154946 \| acute angle-closure glaucoma \| 1 C0019348 \| herpes simplex \| 1 C0004623 \| bacterial infections \| 1 C0015469 \| facial paralysis \| 1 C0014038 \| encephalitis \| 1 C0021053 \| immune disease \| 1 C0018818 \| ventricular septal defect \| 1 C0006309 \| brucellosis \| 1 C0021345 \| mononucleosis \| 1 C0270922 \| demyelinating polyneuropathy \| 1 C0041466 \| typhoid fever \| 1 C0031117 \| peripheral neuropathy \| 1 C0001175 \| acquired immune deficiency \| 1 C0152025 \| polyneuropathy \| 1 C0001175 \| acquired immune deficiency syndrome (aids) \| 1 C0015469 \| facial nerve paralysis \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0020538 \| hypertension \| 1 C0037317 \| sleep disturbances \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0032587 \| polyradiculoneuropathy \| 1 C0001175 \| acquired immune deficiency syndrome \| 1 C0024305 \| non-hodgkin's lymphoma \| 1 C0030442 \| bulbar palsy \| 1 C0041327 \| pulmonary tuberculosis \| 1 C0009377 \| colonic pseudo-obstruction \| 1 C0015464 \| facial palsy \| 1 C0017601 \| glaucoma \| 1 C0021345 \| infectious mononucleosis \| 1 C0017665 \| membranous nephropathy \| 1 C0027121 \| myositis \| 1 C0016735 \| frontal sinusitis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 5376 \| PMP22 \| ORPHANET;UNIPROT 7124 \| TNF \| GHR
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:17) 348 \| APOE \| CIPHER 929 \| CD14 \| CIPHER 909 \| CD1A \| CIPHER 912 \| CD1D \| CIPHER 913 \| CD1E \| CIPHER 2212 \| FCGR2A \| CIPHER 2214 \| FCGR3A \| CIPHER 2215 \| FCGR3B \| CIPHER 3117 \| HLA-DQA1 \| CIPHER 3119 \| HLA-DQB1 \| CIPHER 3123 \| HLA-DRB1 \| CIPHER 3586 \| IL10 \| CIPHER 4153 \| MBL2 \| CIPHER 4318 \| MMP9 \| CIPHER 2908 \| NR3C1 \| CIPHER 7099 \| TLR4 \| CIPHER 7124 \| TNF \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:103) 337 \| APOA4 \| 2.381 \| DISEASES 361 \| AQP4 \| 1.102 \| DISEASES 551 \| AVP \| 2.448 \| DISEASES 627 \| BDNF \| 1.601 \| DISEASES 26005 \| C2CD3 \| 1.16 \| DISEASES 720 \| C4A \| 1.438 \| DISEASES 730 \| C7 \| 2.555 \| DISEASES 774 \| CACNA1B \| 1.15 \| DISEASES 4076 \| CAPRIN1 \| 1.881 \| DISEASES 8573 \| CASK \| 1.135 \| DISEASES 875 \| CBS \| 1.499 \| DISEASES 910 \| CD1B \| 1.812 \| DISEASES 911 \| CD1C \| 1.486 \| DISEASES 913 \| CD1E \| 4.445 \| DISEASES 124599 \| CD300LB \| 4.023 \| DISEASES 959 \| CD40LG \| 5.874 \| DISEASES 966 \| CD59 \| 1.824 \| DISEASES 942 \| CD86 \| 1.918 \| DISEASES 7122 \| CLDN5 \| 2.351 \| DISEASES 23601 \| CLEC5A \| 1.915 \| DISEASES 22866 \| CNKSR2 \| 2.189 \| DISEASES 1270 \| CNTF \| 1.016 \| DISEASES 1272 \| CNTN1 \| 2.176 \| DISEASES 26047 \| CNTNAP2 \| 1.867 \| DISEASES 1471 \| CST3 \| 1.587 \| DISEASES 5476 \| CTSA \| 2.312 \| DISEASES 4283 \| CXCL9 \| 1.038 \| DISEASES 2833 \| CXCR3 \| 1.454 \| DISEASES 51428 \| DDX41 \| 3.216 \| DISEASES 1847 \| DUSP5 \| 1.335 \| DISEASES 124454 \| EARS2 \| 1.074 \| DISEASES 1896 \| EDA \| 2.175 \| DISEASES 2204 \| FCAR \| 1.012 \| DISEASES 50943 \| FOXP3 \| 1.711 \| DISEASES 10146 \| G3BP1 \| 1.087 \| DISEASES 2550 \| GABBR1 \| 1.082 \| DISEASES 2582 \| GALE \| 2.607 \| DISEASES 342035 \| GLDN \| 3.671 \| DISEASES 2719 \| GPC3 \| 2.651 \| DISEASES 3106 \| HLA-B \| 1.133 \| DISEASES 3115 \| HLA-DPB1 \| 1.114 \| DISEASES 3119 \| HLA-DQB1 \| 1.777 \| DISEASES 3120 \| HLA-DQB2 \| 1.508 \| DISEASES 8091 \| HMGA2 \| 4.995 \| DISEASES 3240 \| HP \| 1.639 \| DISEASES 3329 \| HSPD1 \| 1.29 \| DISEASES 3376 \| IARS \| 1.525 \| DISEASES 3423 \| IDS \| 1.449 \| DISEASES 3455 \| IFNAR2 \| 1.251 \| DISEASES 3456 \| IFNB1 \| 2.733 \| DISEASES 3586 \| IL10 \| 2.45 \| DISEASES 3605 \| IL17A \| 2.448 \| DISEASES 50616 \| IL22 \| 1.192 \| DISEASES 27124 \| INPP5J \| 1.743 \| DISEASES 3684 \| ITGAM \| 1.146 \| DISEASES 3767 \| KCNJ11 \| 1.474 \| DISEASES 8284 \| KDM5D \| 1.124 \| DISEASES 9211 \| LGI1 \| 2.371 \| DISEASES 4049 \| LTA \| 2.203 \| DISEASES 4099 \| MAG \| 4.68 \| DISEASES 93487 \| MAPK1IP1L \| 2.933 \| DISEASES 4155 \| MBP \| 3.673 \| DISEASES 9282 \| MED14 \| 3.064 \| DISEASES 4318 \| MMP9 \| 2.119 \| DISEASES 4359 \| MPZ \| 1.269 \| DISEASES 4478 \| MSN \| 1.761 \| DISEASES 4593 \| MUSK \| 2.239 \| DISEASES 342538 \| NACA2 \| 3.004 \| DISEASES 23114 \| NFASC \| 4.538 \| DISEASES 4803 \| NGF \| 2.196 \| DISEASES 51199 \| NIN \| 2.014 \| DISEASES 4897 \| NRCAM \| 1.801 \| DISEASES 100506658 \| OCLN \| 1.098 \| DISEASES 103164619 \| PCAT2 \| 1.206 \| DISEASES 23481 \| PES1 \| 3.378 \| DISEASES 11331 \| PHB2 \| 2.543 \| DISEASES 5251 \| PHEX \| 1.042 \| DISEASES 10687 \| PNMA2 \| 1.843 \| DISEASES 5554 \| PRH1 \| 1.802 \| DISEASES 5555 \| PRH2 \| 1.802 \| DISEASES 5563 \| PRKAA2 \| 1.433 \| DISEASES 5730 \| PTGDS \| 1.965 \| DISEASES 5813 \| PURA \| 1.221 \| DISEASES 387 \| RHOA \| 1.888 \| DISEASES 7732 \| RNF112 \| 1.02 \| DISEASES 6223 \| RPS19 \| 3.01 \| DISEASES 6227 \| RPS21 \| 1.623 \| DISEASES 6280 \| S100A9 \| 1.548 \| DISEASES 6342 \| SCP2 \| 1.097 \| DISEASES 123228 \| SENP8 \| 1.186 \| DISEASES 9047 \| SH2D2A \| 1.86 \| DISEASES 6614 \| SIGLEC1 \| 2.852 \| DISEASES 27036 \| SIGLEC7 \| 3.791 \| DISEASES 55576 \| STAB2 \| 1.806 \| DISEASES 25870 \| SUMF2 \| 1.318 \| DISEASES 6891 \| TAP2 \| 2.259 \| DISEASES 7073 \| TIAL1 \| 1.443 \| DISEASES 7099 \| TLR4 \| 2.187 \| DISEASES 7124 \| TNF \| 3.576 \| DISEASES 7133 \| TNFRSF1B \| 1.25 \| DISEASES 54209 \| TREM2 \| 1.842 \| DISEASES 7456 \| WIPF1 \| 1.337 \| DISEASES 26137 \| ZBTB20 \| 1.292 \| DISEASES
Locus	(Waiting for update.)

Disease ID	192
Disease	guillain-barre syndrome
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:1) HP:0007131 \| Acute demyelinating polyneuropathy
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:72) HP:0012115 \| Liver inflammation \| 6 HP:0003470 \| Inability to move \| 5 HP:0010628 \| Facial palsy, unilateral or bilateral \| 4 HP:0001349 \| Facial paresis, bilateral \| 4 HP:0002878 \| Respiratory failure \| 3 HP:0012531 \| Pain \| 3 HP:0002902 \| Hyponatremia \| 3 HP:0200119 \| Acute liver inflammation \| 3 HP:0012378 \| Fatigue \| 3 HP:0001369 \| Arthritis \| 2 HP:0003477 \| Peripheral axonal neuropathy \| 2 HP:0001298 \| Encephalopathy \| 2 HP:0001347 \| Hyperreflexia \| 2 HP:0001638 \| Cardiomyopathy \| 2 HP:0003390 \| Sensory axonal neuropathy \| 2 HP:0000011 \| Neurogenic bladder \| 1 HP:0002273 \| Tetraparesis \| 1 HP:0430025 \| Bilateral facial paralysis \| 1 HP:0001953 \| Diabetic ketosis \| 1 HP:0009830 \| Peripheral neuritis \| 1 HP:0012393 \| Allergy \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0001324 \| Muscular weakness \| 1 HP:0000979 \| Purpura \| 1 HP:0002203 \| Respiratory paralysis \| 1 HP:0007942 \| Internal ophthalmoplegia \| 1 HP:0012799 \| Unilateral facial weakness \| 1 HP:0002664 \| Neoplasia \| 1 HP:0001629 \| Ventricular septal defects \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0011986 \| Ectopic bone formation \| 1 HP:0001945 \| Fever \| 1 HP:0000100 \| Nephrosis \| 1 HP:0040078 \| Axonal degeneration \| 1 HP:0000127 \| Salt wasting \| 1 HP:0030880 \| Raynaud phenomenon \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0000238 \| Nonsyndromal hydrocephalus \| 1 HP:0003326 \| Muscle pain \| 1 HP:0002318 \| Cervical myelopathy \| 1 HP:0001993 \| Ketoacidosis \| 1 HP:0002608 \| Celiac disease \| 1 HP:0100614 \| Muscle inflammation \| 1 HP:0000501 \| Glaucoma \| 1 HP:0003768 \| Periodic paralysis \| 1 HP:0012819 \| Myocarditis \| 1 HP:0012578 \| Membranous glomerulonephritis \| 1 HP:0001283 \| Bulbar palsies \| 1 HP:0002666 \| Pheochromocytoma \| 1 HP:0002013 \| Emesis \| 1 HP:0011665 \| Takotsubo cardiomyopathy \| 1 HP:0003447 \| Axonal loss \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0000872 \| Hashimoto's thyroiditis \| 1 HP:0001171 \| Hand ectrodactyly \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0003401 \| Paresthesia \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0011349 \| Sixth nerve palsy \| 1 HP:0001336 \| Myoclonic jerks \| 1 HP:0002360 \| Sleep disturbance \| 1 HP:0003396 \| Syringomyelia \| 1 HP:0012452 \| Restless legs \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0006882 \| Severe hydrocephalus \| 1 HP:0000822 \| Hypertension \| 1 HP:0002459 \| Dysautonomia \| 1 HP:0002383 \| Encephalitis \| 1 HP:0007209 \| Facial paresis \| 1 HP:0002196 \| Myelopathy \| 1 HP:0000112 \| Nephropathy \| 1 HP:0002721 \| Immunodeficiency \| 1

Disease ID	192
Disease	guillain-barre syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:20) C2364133 \| infection C2364051 \| fatigue C2108077 \| atrioventricular block C2096315 \| headache C1963137 \| hydrocephalus C1962971 \| myocarditis C1145670 \| respiratory failure C1135207 \| ataxia C0271650 \| impaired glucose tolerance C0239889 \| severe headache C0221165 \| diplegia C0155320 \| cortical blindness C0155288 \| papilledema C0028866 \| oculomotor nerve palsy C0027813 \| neuritis C0027726 \| nephrotic syndrome C0024535 \| plasmodium falciparum malaria C0018378 \| acute inflammatory demyelinating polyradiculoneuropathy C0011860 \| diabetes C0010403 \| cryoglobulinemia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:7) C0009450 \| infection \| 8 C0221165 \| diplegia \| 4 C0015672 \| fatigue \| 3 C1145670 \| respiratory failure \| 3 C0027059 \| myocarditis \| 1 C0027726 \| nephrotic syndrome \| 1 C0020255 \| hydrocephalus \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs397514767	25818314	966	CD59	umls:C0018378	BeFree	The Cys89Tyr mutation in CD59 was clinically manifested in infancy, and associated with chronic hemolysis and relapsing peripheral demyelinating disease resembling recurrent Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP).	0.000271442	2015	CD59	11	33710247	C	T
rs4986790	19913922	7099	TLR4	umls:C0018378	BeFree	Association of TLR4 Asp299Gly and Thr399Ile polymorphisms with Guillain-Barré syndrome in Northern Indian population.	0.000271442	2010	TLR4	9	117713024	A	G
rs4986791	19913922	7099	TLR4	umls:C0018378	BeFree	Association of TLR4 Asp299Gly and Thr399Ile polymorphisms with Guillain-Barré syndrome in Northern Indian population.	0.000271442	2010	TLR4	9	117713324	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0007131	Acute demyelinating polyneuropathy	MP:0013438	dysmyelination	reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin

Disease ID	192
Disease	guillain-barre syndrome
Case	(Waiting for update.)

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